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Agenzia Italiana del Farmaco
Ondexxya (andexanet alfa): Avoid use of andexanet prior to heparinization - Ondexxya (andexanet alfa): Avoid use of andexanet prior to heparinization
Ondexxya (andexanet alfa): Avoid use of andexanet prior to heparinization
Summary
- avoid the use of andexanet alfa before heparinization (e.g. during surgery);
- andexanet alfa causes unresponsiveness to the anticoagulant effects of heparin;
- results of coagulation tests might be misleading when andexanet alfa and heparin are given within a short time of one another. Monitoring of andexanet alfa’s effect has not been validated while heparin is active;
- use of andexanet alfa for FXa reversal before urgent surgery has not been evaluated.
Published on: 10 May 2021
